The integration of artificial intelligence into materials science has enabled autonomous discovery processes that accelerate the identification of novel compounds and structures. However, this advancement introduces scientific risks, including recommendations that may lead to unintended consequences, such as material instability, environmental hazards, or inefficiencies in application. This conceptual paper develops a framework for anticipating these risks by examining interaction dynamics between algorithmic outputs and systemic factors in research ecosystems. Drawing on recent literature, it synthesizes insights into how AI-driven autonomy influences epistemic reasoning and ethical trade-offs in materials discovery. The framework emphasizes steering logics that incorporate feedback structures for risk assessment, highlighting analytical implications for balancing innovation speed with precautionary measures. Through conceptual interpretations of uncertainty propagation and bias amplification, it explores how autonomous systems can inadvertently prioritize short-term optimization over long-term viability. Systems-level insights reveal the need for integrative approaches that align computational recommendations with broader societal and ecological considerations. Ultimately, this work underscores the importance of interpretive vigilance in AI-assisted discovery, offering a pathway to enhance resilience against unsafe outcomes while fostering sustainable progress in applied artificial intelligence for materials science.