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The advent of computational and data-driven materials engineering has transformed the landscape of materials discovery, leveraging machine learning algorithms and high-throughput simulations to accelerate the identification of novel compounds and properties. Within this paradigm, AI-guided systems integrate representation learning, graph neural networks, and uncertainty quantification to navigate vast chemical spaces, yet persistent exploration blind spots arise from incomplete coverage in data infrastructures and model architectures. These blind spots manifest as epistemic gaps where AI-driven searches fail to probe underrepresented regions of materials possibility spaces, potentially overlooking breakthrough innovations. This manuscript introduces the Coverage Dynamics Framework (CDF), a conceptual lens that dissects the interplay between data modalities, representational embeddings, and discovery steering logics to illuminate these blind spots. By framing exploration as a dynamic interplay of coverage vectors and feedback mechanisms, the CDF highlights systemic trade-offs in AI-guided pipelines, such as the tension between exploitation of known datasets and exploration of sparse domains. Implications extend to enhancing autonomous discovery systems, fostering multimodal data integration, and refining uncertainty-aware workflows in materials informatics. Ultimately, this framework advocates for infrastructure-level interventions to mitigate blind spots, promoting more comprehensive and resilient AI-assisted materials engineering ecosystems.