In the evolving landscape of computational and data-driven materials engineering, iterative learning systems have become pivotal for accelerating materials discovery through integrated machine learning pipelines and high-throughput computations. These systems, encompassing active learning loops and closed-loop experimentation, rely on dynamic representations of materials properties and structures to guide successive iterations of model refinement and data acquisition. However, a critical yet underexplored phenomenon emerges: representation drift, where iterative updates inadvertently alter the semantic fidelity of learned embeddings, potentially leading to misaligned inferences across discovery cycles. This conceptual manuscript identifies this gap within materials informatics ecosystems, highlighting how drift manifests in graph neural networks, multimodal datasets, and uncertainty-aware frameworks. To address this, we introduce the Iterative Representation Stabilization Framework (IRSF), a novel conceptual architecture that integrates stabilization mechanisms across data ingestion, model adaptation, and inference steering layers. IRSF conceptualizes drift as a systemic interaction between feedback loops and representation spaces, offering interpretive insights into maintaining epistemic consistency in autonomous discovery workflows. Implications extend to enhancing the robustness of foundation models for science, simulation-experiment couplings, and inverse design paradigms, fostering more reliable computational steering in materials engineering. By framing representation drift through infrastructure-level trade-offs, this work provides a foundational lens for interpreting iterative dynamics, ultimately supporting sustainable advancements in data-driven materials paradigms.